Francisco Fernández may refer to:
Nobility
Francisco Fernández de la Cueva, 2nd Duke of Alburquerque (1467–1526), Spanish noble
Francisco Fernández de la Cueva, 4th Duke of Alburquerque (1510–1563), Spanish noble
Francisco Fernández de la Cueva, 7th Duke of Alburquerque (1575–1637), Spanish noble
Francisco Fernández de la Cueva, 8th Duke of Alburquerque (1619–1676), Spanish military officer and governor of New Spain
Francisco Fernández de la Cueva, 10th Duke of Alburquerque (1666–1724), viceroy of New Spain
Politics and law
Francisco Fernández de Béthencourt (1850–1916), Spanish politician
Francisco Fernández Ordóñez (1930–1992), Spanish politician
Francisco Fernández Marugán (1946–2025), Spanish politician
Francisco Fernández de Cevallos (born 1947), Mexican politician
Francisco Javier Fernández (politician) (born 1969), Spanish politician
Francisco Montealegre Fernández (1818–1875), Costa Rican politician and businessman
Francisco Sanz Fernández (born 1952), Spanish politician
Sports
Gallego (footballer) (Francisco Fernández Rodríguez, born 1944), Spanish international footballer of the 1960s
Francisco Fernández Ochoa (1950–2006), Spanish alpine skier
Francisco Fernández Moreno (born 1954), Spanish road bicycle racer
Francisco Fernández (Chilean footballer) (born 1975), Chilean association football player
Paquillo Fernández (Francisco Javier Fernández, born 1977), Spanish racewalker
Francisco Fernández (water polo) (born 1986), Spanish water polo player
Others
Francisco Fernández (artist) (1606–1646), Spanish painter
Francisco Fernández Carvajal (1938–2026), Spanish priest and author
Francisco Fernández (supercentenarian) (1901–2012), Spanish supercentenarian