John or Jon Holmes may refer to:
Arts and entertainment
John Holmes (actor) (1944–1988), American pornographic actor and murder suspect
John Holmes (composer) (died 1629), English musician and composer
John Holmes (poet) (1904–1962), American poet
John Clellon Holmes (1926–1988), American Beat poet, novelist and essayist
John Eric Holmes (1930–2010), American author and promoter of fantasy role-playing games
John W. Holmes (film editor) (1917–2001), American film editor
John Holmes (radio presenter) MBE, associated with BBC Radio 4 and BBC Radio Nottingham
Jon Holmes (born 1973), British comedy writer and broadcaster
Diplomacy
John Holmes (British diplomat) (born 1951), British diplomat
John T. Holmes, Canadian ambassador to Indonesia and East Timor
John Wendell Holmes (1910–1988), Canadian diplomat and academic
Education
John Holmes (geographer), Australian professor of geography
John Holmes (schoolmaster) (1703–1760), English schoolmaster
John Clough Holmes (1809–1887), American merchant; Agricultural College of the State of Michigan progenitor
Military or mercenary service
John Holmes (British Army officer) (born 1949), British general
John Holmes (mercenary), 19th century Anglo-Indian mercenary
John Holmes (Royal Navy officer) (1640?–1683), English naval officer
Politics
John Holmes (by 1529 – 1583), MP for Ripon and Boroughbridge
John Holmes (died 1556 or later), MP for Rye
John Holmes (Maine politician) (1773–1843), member of U.S. Senate and U.S. House of Representatives
John Holmes (New Zealand politician) (1831–1910), New Zealand Member of Parliament
John Holmes (Nova Scotia politician) (1789–1876), Canadian Senator
John Holmes (Ontario politician) (1828–1879), Canadian MP
John Bee Holmes (1760–1827), intendant (mayor) of Charleston, South Carolina
John Edwin Holmes (1809–1863), first Lieutenant Governor of Wisconsin
John Robert Holmes (1927–2011), Canadian MP
John Holmes (Jamaican politician) (1763–1836), planter, slave-owner and member of the House of Assembly of Jamaica
Religion
John Holmes (bishop) (died 1904), Anglican colonial bishop
John Haynes Holmes (1879–1964), American churchman and pacifist
John McClellan Holmes (1834–1911), Christian minister and author
Sports
John Holmes (footballer) (1869–?), English footballer
John Holmes (cricketer) (Rodney Holmes, 1924–1980), English cricketer
Johnny Holmes, American baseball player of the 1940s
John Holmes (rugby league) (1952–2009), English former rugby league footballer
John Holmes (rugby league, born 1904) (1904–1931), Australian rugby league player
John Holmes (golfer) (JB Holmes, born 1982), American golfer
John Holmes (American football) (born 1953), American football player
Other fields
John Holmes (antiquary) (1800–1854), English antiquarian
John Holmes (essayist) (1815–1894), radical campaigner
John Holmes (Messenger of the Plymouth Court) (1603–?), Plymouth Colony settler and official
John Henry Holmes (1857–1935), English electrical engineer, inventor and Quaker
John Dalrymple Edgar Holmes (1867–1915), British veterinary scientist and bacteriologist
Fictional characters
John Hamish Adler Holme or Auguste Lupa, a fictional character in novels by John Lescroart